Hyperlipidemia is commonly observed in the diabetics, especially with cardiovascular complications.
We studied lipid profiles and cardiovascular complication in the 191 adult onset DM patients.
The results are as follows：
1. The age distribution was from 24 years old to 82 years old. Male patients were 99 persons, famale patients were 92 persons.
The mean disease duration was less than 2 years in the 77 patients, more than 5 years in the 79 patients.
2. Upon the classification between sexes, the mean age was 55± 1(SEM) years in the male group, 53± 1(SEM) years in the female group.
The mean disease durtion was 6.4± 0.6(SEM) years in the male group, 4.3± 0.5(SEM) in the female group, longer in the male group (P<0.05).
The triglyceride level was 210± 16(SEM)mg％ in the male group, 214± 13(SEM)mg％ in the female group. The fasting blood sugar level was 147± 6(SEM)mg/dl in the male group, 153± 8(SEM)mg/dl in the female group. The cholesterol level was 229± 5(SEM)mg/dl in the male group, 248± 5(SEM) mg/dl in the female group, higher in the female group (P<0.05).
3. The cardiovascurlar complication (Hypertension, Myocardial infarction, Myocardial ischemia, Angina, Gangrene, Proliferative retinopathy) were present in the 60 patients from 191 patients. Hypertension was present in the 48 patients, and the most prevalent.
The mean age and carrdiovascular complication were higher in the more than 5 years of mean disease duration group(mean age 57.99± 1.14SEM year) than less than 5 years group(mean age 52.12± 0.10SEM year) (P<0.001, P<0.01).
4. The mean disease duration (7.40±1.01SEM years), mean triglyceride levels (271±1.01SEM mg％), and mean cholesterol levels (257±8mg/dl) in the cardiovascularly complicated group were higher than those of non-complicated group (P<0.01).
5. The triglyceride level was high in the obese group (230±14SEM mg％ ) than non-obese group (184±15SEM mg％) (P<0.05).
The obese patients were more prevalent in the female group than male group significantly.
6. Considering obesity and cardiovascular complications, the triglyceride value was higher in the obese complicated group(300±30 SEM mg％) than obese non-complicated (197±14 SEM mg％) or non-obese non-complicated (168±13 SEM mg％) group(P<0.001).
The cholesterol level was higher in the obese complicated group (267±10 SEM mg/dl) than obese non-complicated (230±5 SEM mg/dl) or non-obese non-complicated group (229±7 SEM mg/dl) (P<0.05).
7. Classifying upon insulin response pattern, the obese patients were found in the response pattern, low response pattern, flat type pattern (no response pattern) in the decreasing number of order (P<0.01).
The cardiovascular complications were found in the low response group, response group, and flat type pattern (no response) in the decreasing number of order (P<0.05).
The combined cases of obesity and cardiovascular complications were found in the low response group, response group and flat type group (no response) pattern in the decreasing number of order (P<0.01).
The mean disease duration was longer in the flat type group (no response) (4.48±0.6 SEM years) than the response group(2.43±0.90SEM years) (P<0.05).
The mean triglyceride value was higher in the response group (267.38±154.75SEM mg％) than the flat type(no response group) (198.35±154.05SDmg％) (P<0.05).
So, we conclude that in the NIDDM, obesity control(die control, ideal body weight maintence, and hyperlipidemia control) is essential for better DM control and cardiovascular complication control.
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